Now Is the Time for Running focuses primarily upon the bond between Deo and Innocent as they flee Zimbabwe and struggle to survive in South Africa. From his earliest years, Deo has always been aware that it is his responsibility to take care of Innocent, even though his brother is 10 years his senior. Although Deo sometimes finds Innocent’s behavior frustrating, the two remain close throughout their ordeal. Deo understands Innocent’s needs when nobody else does. He recognizes that while batteries for Innocent’s radio might not seem like a vital necessity, they will make a big difference to Innocent’s well-being. The brothers are always able to overcome their brief conflicts, such as when Deo loses his temper after Philani’s betrayal of them both.

Ultimately, Deo and Innocent are stronger and happier as long as they are able to stay together and rely on each other. Their greatest struggles and hardships occur when they are apart. At the beginning of the book, for example, the invading soldiers beat Innocent when Deo is not there to protect him. The next time they get separated is in Alexandra Township, and, that time, Deo is unable to find his brother in time to prevent Innocent from being murdered.